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Our great River has influenced life in the Americas for hundreds of years. As human consumption has changed, we have also had a greater, often harmful, impact on the River as well. Because of the River's vast tributary system, you don't have to live on the River to impact its waters. Learn more about the human relationship with the Mississippi River in these five subject-specific fact sheets on River Wildlife, Economies and Communities, Water Quality and Drinking Water, River Flow, and the Dead Zone.